{"id":10401,"date":"2019-08-26T13:27:42","date_gmt":"2019-08-26T13:27:42","guid":{"rendered":"https:\/\/myuberdiet.com\/plan\/?p=10401"},"modified":"2020-01-09T10:05:53","modified_gmt":"2020-01-09T10:05:53","slug":"does-it-get-any-better-than-berberine","status":"publish","type":"post","link":"https:\/\/myuberdiet.com\/plan\/does-it-get-any-better-than-berberine\/","title":{"rendered":"Does it get any better than Berberine?"},"content":{"rendered":"\n<p><strong>What is Berberine?<\/strong><\/p>\n\n\n\n<p>Berberine is an alkaloid\nfound in many species of the plant genus&nbsp;<em>Berberis<\/em>, as well as shrubs\nand trees in the poppy and cork families.&nbsp;Berberine has a long history of use in traditional Chinese\nmedicine, where it was used to treat various ailments.<\/p>\n\n\n\n<p><strong>Showing impressive clinical applications for: <\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Hypertension (1)<\/li><li>Blood sugar control\n(2)<\/li><li>Cholesterol (3)<\/li><li>Diabetes (4)<\/li><li>PCOS (5)<\/li><li>Obesity (6)<\/li><li>Cancer (7)<\/li><li>Depression (8)<\/li><li>Antioxidant &amp;\nanti-inflammatory (9)<\/li><li>Fatty Liver (10)<\/li><li>Infections (11)<\/li><li>Heart Faliure (12)<\/li><\/ul>\n\n\n\n<p><strong>How Does it work?<\/strong><\/p>\n\n\n\n<p>Berberine activates an enzyme inside the cells called\nAMP-activated protein kinase (AMPK) (<a href=\"https:\/\/diabetes.diabetesjournals.org\/content\/55\/8\/2256.full\">13<\/a>). AMPK is also referred to as the \u201cmetabolic master\nswitch\u201d (14). This enzyme is found in the cells of the brain, heart, liver,\nkidney and muscle. AMPK plays a&nbsp;<strong>major<\/strong>&nbsp;role in\nregulating metabolism.(15)(16)<\/p>\n\n\n\n<p><strong>Low AMPK activity leads to: <\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Accelerated ageing<\/li><li>Inflammation<\/li><li>Insulin resistance<\/li><li>Increased belly fat<\/li><li>Dysglycemia<\/li><li>Raised cholesterol <\/li><li>High triglycerides<\/li><li>Obesity<\/li><li>Possible diabetes<\/li><li>Mitochondrial insufficiency\n&amp; dysfunction<\/li><li>Neurodegeneration<\/li><\/ul>\n\n\n\n<p><strong>Dosage:<\/strong><\/p>\n\n\n\n<p>A common dosage recommendation is 500 mg, 3 times per\nday, half an hour before meals. Berberine may cause digestive side effects in\nsome people. Start on one a day and slowly build up to 3 times per day.<\/p>\n\n\n\n<p>Berberine has a great safety profile. The main side\neffects are related to digestion, such as cramping, diarrhea, flatulence,\nconstipation and stomach pain. (17)<\/p>\n\n\n\n<p>If you have a medical condition or you are on any\nmedications, then speak to your doctor before taking it.\n\nDo not use\nduring pregnancy or lactation\n\n\n\n<\/p>\n\n\n\n<p class=\"has-text-align-center\"><strong><a href=\"https:\/\/amzn.to\/2T2bOVJ\" target=\"_blank\" rel=\"noreferrer noopener\" aria-label=\"Berberine (opens in a new tab)\">Berberine<\/a><\/strong><\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-large is-resized\"><a href=\"https:\/\/amzn.to\/2T2bOVJ\" target=\"_blank\" rel=\"noreferrer noopener\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/myuberdiet.com\/plan\/wp-content\/uploads\/2019\/08\/Berberine-Amazon-Pic.png\" alt=\"\" class=\"wp-image-10404\" width=\"237\" height=\"368\" srcset=\"https:\/\/myuberdiet.com\/plan\/wp-content\/uploads\/2019\/08\/Berberine-Amazon-Pic.png 251w, https:\/\/myuberdiet.com\/plan\/wp-content\/uploads\/2019\/08\/Berberine-Amazon-Pic-193x300.png 193w\" sizes=\"auto, (max-width: 237px) 100vw, 237px\" \/><\/a><\/figure><\/div>\n\n\n\n<p><a href=\"https:\/\/amzn.to\/2T2bOVJ\" target=\"_blank\" rel=\"noreferrer noopener\" aria-label=\"Click here (opens in a new tab)\">Click here<\/a> to get Your Berberine<\/p>\n\n\n\n<p>References<\/p>\n\n\n\n<p>(1)Flora\nAffuso, Valentina Mercurio, Valeria Fazio, and Serafino Fazio. Cardiovascular\nand metabolic effects of Berberine.<\/p>\n\n\n\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2999047\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2999047\/<\/a><\/p>\n\n\n\n<p>(2)\nPang B1, Zhao LH2, Zhou Q3, Zhao TY1, Wang H1, Gu CJ1,\nTong XL1. Application of berberine on treating type 2 diabetes mellitus. <\/p>\n\n\n\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25861268\">https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25861268<\/a><\/p>\n\n\n\n<p>(3)Dong\nH1, Zhao Y, Zhao L, Lu F. The effects of berberine on blood lipids: a systemic\nreview and meta-analysis of randomized controlled trials.<\/p>\n\n\n\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23512497\">https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23512497<\/a><\/p>\n\n\n\n<p>(4)Chang\nW1, Chen L2, Hatch GM1,3. Berberine as a therapy for type 2 diabetes and its\ncomplications: From mechanism of action to clinical studies. <\/p>\n\n\n\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25607236\">https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25607236<\/a><\/p>\n\n\n\n<p>(5)Wei\nW1, Zhao H, Wang A, Sui M, Liang K, Deng H, Ma Y, Zhang Y, Zhang H, Guan Y. A\nclinical study on the short-term effect of berberine in comparison to metformin\non the metabolic characteristics of women with polycystic ovary syndrome.<\/p>\n\n\n\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22019891\">https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22019891<\/a><\/p>\n\n\n\n<p>(6)Jing\nYang, 1 Jinhua Yin, 1 , 2 Hongfei Gao, 1 Linxin Xu, 1 , 2 Yan Wang, 1 Lu Xu, 2\nand Ming Li 2. Berberine Improves Insulin Sensitivity by Inhibiting Fat Store\nand Adjusting Adipokines Profile in Human Preadipocytes and Metabolic Syndrome\nPatients. <\/p>\n\n\n\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3310165\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3310165\/<\/a><\/p>\n\n\n\n<p>&nbsp;(7) Sun, Yiyia; Xun,\nKelib; Wang, Yitaoc; Chen, Xiupingc. A systematic review of the anticancer\nproperties of berberine, a natural product from Chinese herbs. <\/p>\n\n\n\n<p><a href=\"https:\/\/journals.lww.com\/anti-cancerdrugs\/Abstract\/2009\/10000\/A_systematic_review_of_the_anticancer_properties.1.aspx\">https:\/\/journals.lww.com\/anti-cancerdrugs\/Abstract\/2009\/10000\/A_systematic_review_of_the_anticancer_properties.1.aspx<\/a><\/p>\n\n\n\n<p>(8)Kulkarni\nSK1, Dhir A. On the mechanism of antidepressant-like action of berberine\nchloride.<\/p>\n\n\n\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18585703\">https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18585703<\/a><\/p>\n\n\n\n<p>(9)Lou\nT1, Zhang Z, Xi Z, Liu K, Li L, Liu B, Huang F. Berberine inhibits inflammatory\nresponse and ameliorates insulin resistance in hepatocytes.Lou T1, Zhang Z, Xi\nZ, Liu K, Li L, Liu B, Huang F.<\/p>\n\n\n\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21110076\">https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21110076<\/a><\/p>\n\n\n\n<p>(10)Yang\nLiu,1 Li Zhang,1 Haiyan Song,1 and Guang Ji1,2 Update on Berberine in\nNonalcoholic Fatty Liver Disease<\/p>\n\n\n\n<p><a href=\"https:\/\/www.hindawi.com\/journals\/ecam\/2013\/308134\/\">https:\/\/www.hindawi.com\/journals\/ecam\/2013\/308134\/<\/a><\/p>\n\n\n\n<p>(11)Cern\u00e1kov\u00e1\nM1, Kost\u00e1lov\u00e1 D. Antimicrobial activity of berberine&#8211;a constituent of Mahonia\naquifolium.<\/p>\n\n\n\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12422513\">https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12422513<\/a><\/p>\n\n\n\n<p>(12)Zeng\nXH1, Zeng XJ, Li YY. Efficacy and safety of berberine for congestive heart\nfailure secondary to ischemic or idiopathic dilated cardiomyopathy. <\/p>\n\n\n\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12860219\">https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12860219<\/a><\/p>\n\n\n\n<p>(13)Yun\nS. Lee12, Woo S. Kim12, Kang H. Kim12, Myung J. Yoon1, Hye J. Cho1, Yun Shen34,\nJi-Ming Ye3, Chul H. Lee5, Won K. Oh5, Chul T. Kim5, Cordula Hohnen-Behrens3,\nAlison Gosby3, Edward W. Kraegen3, David E. James3 and Jae B. Kim12 Berberine,\na Natural Plant Product, Activates AMP-Activated Protein Kinase With Beneficial\nMetabolic Effects in Diabetic and Insulin-Resistant States<\/p>\n\n\n\n<p><a href=\"https:\/\/diabetes.diabetesjournals.org\/content\/55\/8\/2256.full\">https:\/\/diabetes.diabetesjournals.org\/content\/55\/8\/2256.full<\/a><\/p>\n\n\n\n<p>(14)\nWinder WW1, Hardie DG. AMP-activated protein kinase, a\nmetabolic master switch: possible roles in type 2 diabetes.<\/p>\n\n\n\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10409121\">https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10409121<\/a><\/p>\n\n\n\n<p>(15)\nStapleton D1, Mitchelhill KI, Gao G, Widmer J, Michell BJ,\nTeh T, House CM, Fernandez CS, Cox T, Witters LA, Kemp BE. Mammalian\nAMP-activated protein kinase subfamily.<\/p>\n\n\n\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8557660\">https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8557660<\/a><\/p>\n\n\n\n<p>(16)\nMhairi C. Towler&nbsp;\nand D. Grahame Hardie. AMP-Activated Protein Kinase in Metabolic Control\nand Insulin Signaling<\/p>\n\n\n\n<p><a href=\"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.res.0000256090.42690.05\">https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.res.0000256090.42690.05<\/a><\/p>\n\n\n\n<p>(17)Yin\nJ1, Xing H, Ye J. Efficacy of berberine in patients with type 2 diabetes\nmellitus.<\/p>\n\n\n\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18442638\">https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18442638<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>What is Berberine? Berberine is an alkaloid found in many species of the plant genus&nbsp;Berberis, as well as shrubs and trees in the poppy and cork families.&nbsp;Berberine has a long history of use in traditional Chinese medicine, where it was used to treat various ailments. Showing impressive clinical applications for: Hypertension (1) Blood sugar control [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":10407,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[49,18],"tags":[110,112,111],"class_list":["post-10401","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ketogenic-diet","category-scientific-proof-weight-loss","tag-berberine","tag-insulin","tag-pcos"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Does it get any better than Berberine? - My \u00dcber Diet<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/myuberdiet.com\/plan\/does-it-get-any-better-than-berberine\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Does it get any better than Berberine? - My \u00dcber Diet\" \/>\n<meta property=\"og:description\" content=\"What is Berberine? 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Berberine is an alkaloid found in many species of the plant genus&nbsp;Berberis, as well as shrubs and trees in the poppy and cork families.&nbsp;Berberine has a long history of use in traditional Chinese medicine, where it was used to treat various ailments. 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